Is Spravato® The Right Therapy for You?
You may be a candidate for Spravato® therapy if you:
Is Spravato® The Right Therapy for You?
You may be a candidate for Spravato® therapy if you:
Treatment-Resistant Depression
Suicidal Ideation
Seeking Faster Relief
Previous Medications
You have been diagnosed with Major Depressive Disorder (MDD).
You have acute suicidal ideation or behavior.
You are looking for a treatment that can begin working sooner than traditional 4-6 week medication cycles.
You have tried two or more oral antidepressants (of adequate dose and duration) in your current episode without success.
Treatment-Resistant Depression
You have been diagnosed with Major Depressive Disorder (MDD).
Suicidal Ideation
You have tried two or more oral antidepressants (of adequate dose and duration) in your current episode without success.
Seeking Faster Relief
You are looking for a treatment that can begin working sooner than traditional 4-6 week medication cycles.
Previous Medications
You have tried two or more oral antidepressants (of adequate dose and duration) in your current episode without success.
How Spravato® Works: A Neurological Reset
Spravato works differently than traditional antidepressant medications, acting on NMDA receptors which receive signals from the neurotransmitter (chemical messenger) glutamate. This is one reason that Spravato® has a unique effect on reducing the negativity of depression and suicidal ideation.
What to Expect During Your Visit
In-Office Administration
Monitored Recovery
Plan For a Driver
Spravato® is a nasal spray administered by the clinical staff. You will be in a private, comfortable room designed for relaxation.
For your safety, you will remain in our clinic for two hours following administration. We monitor your vitals while you relax, listen to music, or rest as the medication takes effect.
Because Spravato® can cause temporary sleepiness or dizziness, you must arrange transportation to drive you home after each appointment.
In-Office Administration
Spravato is a nasal spray you self-administer under the direct supervision of our clinical staff. You will be in a private, comfortable room designed for relaxation.
Monitored Recovery
For your safety, you will remain in our clinic for two hours following administration. We monitor your vitals while you relax, listen to music, or rest as the medication takes effect.
Plan for a Driver
Because Spravato can cause temporary sleepiness or dizziness, you must have a trusted contact drive you home. You will be ready to drive again the following morning.
Determine if You Are a Candidate for Spravato
Submit an Inquiry Form or Call the Office @ +1 (847) 541-4878; Option 1*
Whether you have a question about our consultations or need a comprehensive evaluation and guidance, we are here to help. Reach out by phone or use the form below and we’ll get back to you ASAP.
Business hours:
Monday – Friday: 7AM – 7PM
Accepted Insurances
Frequently Asked Questions
How is Spravato® therapy different than normal, oral antidepressants?
Traditional antidepressants (SSRIs/SNRIs) target serotonin and can take weeks to work. Spravato® (esketamine) is a nasal spray that targets the glutamate system and NMDA receptors. Because it works on different neural pathways, many patients who haven’t found relief from oral medications see a significant improvement in their depressive symptoms with Spravato.
Is Spravato® therapy covered by insurance?
Yes, Spravato® is FDA-approved for Treatment-Resistant Depression (TRD) and is covered by most major insurance plans, including Medicare. At You First Neuro, our team handles the entire prior authorization and REMS enrollment process to ensure your treatment is accessible and affordable.
What are the common side effects of esketamine nasal spray?
The most common side effects include temporary dissociation (a “floating” sensation), dizziness, nausea, and a mild increase in blood pressure. Because of these effects, the FDA requires patients to be monitored by clinical staff for two hours in-office. These sensations are temporary and usually resolve shortly after the observation period.
How many Spravato® therapy sessions will I need to see results?
Every patient is different, but the standard induction phase typically involves two sessions per week for the first four weeks. Following this, Dr. Frank will evaluate your progress to determine a maintenance schedule, which usually reduces to once a week or every other week.
Will Spravato® therapy work if I’ve already tried multiple SSRIs and failed?
Yes. In fact, that is exactly who this therapy is designed for. SSRIs focus on serotonin, but Spravato® works on synaptic plasticity, literally helping your brain regrow the neural connections that have been damaged by chronic depression. If your “serotonin” pathway isn’t the issue, targeting the glutamate pathway often provides the breakthrough you’ve been looking for.
What's the difference between Spravato® and Esketamine?
Spravato® is the brand name of the specific nasal spray medication, while esketamine is the name of the active pharmaceutical ingredient. They are one and the same. Because it is administered as a nasal spray in a highly regulated, FDA-approved clinical setting, Spravato® is specifically designed and cleared for the treatment of Treatment-Resistant Depression (TRD) and Major Depressive Disorder with suicidal thoughts.
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